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Smolen2018 - Paradoxical LTP maintenance with inhibition of protein synthesis and the proteasome


ABSTRACT: This is a mathematical model describing the formation of long-term potentiation (LTP) at the Schaffer collateral of CA1 pyramidal cell synapse. The model consists of nine ordinary differential equations that denote synaptic states associated with different degrees of LTP, as well as the levels of regulatory proteins involved in the formation and maintenance of LTP.

SUBMITTER: Johannes Meyer  

PROVIDER: BIOMD0000000853 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Paradoxical LTP maintenance with inhibition of protein synthesis and the proteasome suggests a novel protein synthesis requirement for early LTP reversal.

Smolen Paul P   Baxter Douglas A DA   Byrne John H JH  

Journal of theoretical biology 20180821


The transition from early long-term potentiation (E-LTP) to late long-term potentiation (L-LTP) is a multistep process that involves both protein synthesis and degradation. The ways in which these two opposing processes interact to establish L-LTP are not well understood, however. For example, L-LTP is attenuated by inhibiting either protein synthesis or proteasome-dependent degradation prior to and during a tetanic stimulus (e.g., Huang et al., 1996; Karpova et al., 2006), but paradoxically, L-  ...[more]

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