Dataset Information

Jiao2018 - Feedback regulation in a stem cell model with acute myeloid leukaemia

ABSTRACT: This is a mathematical model describing the hematopoietic lineages with leukemia lineages, as controlled by end-product negative feedback inhibition. Variables include hematopoietic stem cells, progenitor cells, terminally differentiated HSCs, leukemia stem cells, and terminally differentiated leukemia stem cells.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000898 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Feedback regulation in a stem cell model with acute myeloid leukaemia.

Jiao Jianfeng J Luo Min M Wang Ruiqi R

BMC systems biology 20180424 Suppl 4

<h4>Background</h4>The haematopoietic lineages with leukaemia lineages are considered in this paper. In particular, we mainly consider that haematopoietic lineages are tightly controlled by negative feedback inhibition of end-product. Actually, leukemia has been found 100 years ago. Up to now, the exact mechanism is still unknown, and many factors are thought to be associated with the pathogenesis of leukemia. Nevertheless, it is very necessary to continue the profound study of the pathogenesis ...[more]

PMID: 29745850

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