Dataset Information

Ota2015 - Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs (GDI integrated)

ABSTRACT: This is a ordinary differential equation mathematical model describing the Rho GTPase cycle in which Rho GDP-dissociation inhibitors (RhoGDIs) inhibit the regulatory activities of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) by interacting with them directly as well as by sequestering the Rho GTPases. The model was constructed with the intent of analyzing the role of RhoGDIs in Rho GTPase signaling.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000899 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000899?filename=Ota2015_GDI-integrated-biopax2.owl	Owl
	BIOMD0000000899?filename=Ota2015_GDI-integrated-biopax3.owl	Owl
	BIOMD0000000899?filename=Ota2015_GDI-integrated-matlab.m	Other
	BIOMD0000000899?filename=Ota2015_GDI-integrated.cps	Other
	BIOMD0000000899?filename=Ota2015_GDI-integrated.ode	Other

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Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs.

Ota Takahide T Maeda Masayo M Okamoto Mayumi M Tatsuka Masaaki M

BMC systems biology 20150128

<h4>Background</h4>Rho GTPases function as molecular switches in many different signaling pathways and control a wide range of cellular processes. Rho GDP-dissociation inhibitors (RhoGDIs) regulate Rho GTPase signaling and can function as both negative and positive regulators. The role of RhoGDIs as negative regulators of Rho GTPase signaling has been extensively investigated; however, little is known about how RhoGDIs act as positive regulators. Furthermore, it is unclear how this opposing role ...[more]

PMID: 25628036

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