Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dubey2007 - A mathematical model for the effect of toxicant on the immune system (without toxicant effect) Model1

ABSTRACT: In this paper, a nonlinear mathematical model is proposed and analyzed to study the effect of environmental toxicant on the immune response of the body. Criteria for local stability, instability and global stability are obtained. It is shown that the immune response of the body decreases as the concentration of environmental toxicant increases, and certain criteria are obtained under which it settles down at its equilibrium level. In the absence of toxicant, an oscillatory behavior of immune system and pathogenic growth is observed. However, in the presence of toxicant, oscillatory behavior is not observed. These studies show that the toxicant may have a grave effect on our body’s defense mechanism. Keywords: Pathogen; Immune Response; Toxicant; Stability.

SUBMITTER: Mohammad Umer Sharif Shohan

PROVIDER: BIOMD0000000906 | BioModels | 2024-09-02

REPOSITORIES: BioModels

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	BIOMD0000000906?filename=Dubey2007_model1-biopax2.owl	Owl
	BIOMD0000000906?filename=Dubey2007_model1-biopax3.owl	Owl
	BIOMD0000000906?filename=Dubey2007_model1-matlab.m	Other
	BIOMD0000000906?filename=Dubey2007_model1-octave.m	Other
	BIOMD0000000906?filename=Dubey2007_model1.cps	Other

Items per page:

1 - 5 of 12

Similar Datasets

Dubey2007 - A mathematical model for the effect of toxicant on the immune system (with toxicant effect) Model2

Project description:In this paper, a nonlinear mathematical model is proposed and analyzed to study the effect of environmental toxicant on the immune response of the body. Criteria for local stability, instability and global stability are obtained. It is shown that the immune response of the body decreases as the concentration of environmental toxicant increases, and certain criteria are obtained under which it settles down at its equilibrium level. In the absence of toxicant, an oscillatory behavior of immune system and pathogenic growth is observed. However, in the presence of toxicant, oscillatory behavior is not observed. These studies show that the toxicant may have a grave effect on our body’s defense mechanism. Keywords: Pathogen; Immune Response; Toxicant; Stability.

2024-09-02 | BIOMD0000000905 | BioModels

A comprehensive characterization of the viscoelastic properties of Bovine Submaxillary Mucin (BSM) and the effect of additives

Project description:This study presents a comprehensive characterization of the viscoelastic and structural properties of Bovine Submaxillary Mucin (BSM), a good biomaterial model system for mucins and mucus in general. We conducted concentration studies of BSM and examined the effects of various additives - sodium chloride, calcium chloride, lysozyme, and DNA - on its rheological behavior. Through oscillatory and shear flow macrorheological experiments, we established a detailed correlation between the concentration of BSM and its viscoelastic properties, uncovering changes in the rheological moduli with the addition of sodium and calcium chloride, particularly at higher concentrations. This highlights the mucins responsiveness to ionic strength and composition variations. The presence of lysozyme and DNA further influenced the rheological characteristics of BSM, adding a new dimension to our understanding of mucin behavior. The rheological spectra could be well-described by a Fractional Kelvin-Voigt Model (FKVM), which allows to describe the complete behavior with a minimum of model parameters. A detailed proteomics analysis provided insight into the molecular interactions within BSM, enhancing our understanding of its structural intricacies. Complementing this, cryo-scanning electron microscopy (cryo-SEM) was employed to visualize the microstructural alterations and network properties in relation to the rheological data. By elucidating the complex interplay between mucin concentration, environmental conditions, and viscoelastic properties, this research significantly contributes to the field of mucus research and lays an important basis for future studies and advanced applications of numerous mucin-based biomaterials.

2024-07-25 | PXD048381 | Pride

ERK Oscillation-Dependent Gene Expression Patterns and Deregulation By The Stress-Response

2014-03-13 | GSE55823 | GEO

ERK Oscillation-Dependent Gene Expression Patterns and Deregulation By The Stress-Response

Project description:Studies were undertaken to determine whether oscillatory behavior in the extracellular signal regulated kinase (ERK) pathway results in unique gene regulation patterns. Microarray analysis was performed on three subcloned populations of human keratinocytes with distinct ERK signaling/oscillation phenotypes. Microarray analysis identified 45 genes that overlapped between 2 subclones with oscillation phenotypes but not in the subclone which is non-oscillatory. Transcription factor networks revealed a role for MED1 in mediating ERK oscillation-dependent gene expression, which was confirmed with Western blot analysis. Further experimentation confirmed a role for p38 in the mediation of MED1 phosphorylation and ERK oscillatory behavior. hTERT-immortalized normal human keratinocytes (provided by Dr. Jerry Shay, The University of Texas Southwestern Medical Center) were stably transfected with ERK1-green fluorescent protein chimera and stable subclones were isolated with distinct ERK activation/oscillation patterns: Clone #1 exhibits transient ERK activation with ligand activation but does not oscillate; Clone #2 exhibits persistent ERK oscillations that are dependent on ligand activation; and Clone #3 exhibits spontaneous ERK oscillations in the absence of ligand activation.

2014-03-13 | E-GEOD-55823 | biostudies-arrayexpress

Al-Tuwairqi2020 - Dynamics of cancer virotherapy with immune response

Project description:This ordinary differential equation model of the role of the immune response in cancer virotherapy dynamics is described in the publication: Al-Tuwairqi, S.M., Al-Johani, N.O., Simbawa, E.A. "Modeling dynamics of cancer virotherapy with immune response." Adv Differ Equ 2020, 438 (2020). DOI: 10.1186/s13662-020-02893-6 Comment: This model is represented by the system described in Equation 2 of the publication manuscript. Abstract: Virotherapy is a therapeutic treatment for cancer. It uses genetically engineered viruses to selectively infect, replicate in, and destroy cancer cells without damaging normal cells. In this paper, we present a modified model to include, within the dynamics of virotherapy, the interaction between uninfected tumor cells and immune response. The model is analyzed qualitatively to produce five equilibrium points. One of these equilibriums demonstrates the effect observed in virotherapy, where the immune system demolishes infected cells as well as viruses. Moreover, the existence and stability of the equilibrium points are established under certain criteria. Numerical simulations are performed to display the agreement with the analytical results. Finally, parameter analysis is carried out to illustrate which parameters in the model affect the outcome of virotherapy.

2024-09-02 | BIOMD0000001035 | BioModels

Impact of Visceral Fat on Gene Expression Profile in Peripheral Blood Cells

Project description:We profiled gene expression in peripheral blood cells from 28 obese patients by microarray analysis and visceral fat accumulation caused the gene expression proliles especially in circadian rhythm, inflammation, oxidative stress, and immune response. Obesity was defined as body mass index (BMI) greater than 25 kg/m2 according to the Japanese criteria and visceral fat area (VFA) was estimated by abdominal bioelectrical impedance analysis. Subjects with type 1 diabetes mellitus, autoimmune diseases, malignant diseases, and infectious diseases were excluded. Patients treated with statin and/or thiazolidinediones were also excluded.

2014-01-01 | E-GEOD-28038 | biostudies-arrayexpress

Proteomics reveals benzene-caused spleen injury

Project description:Benzene is a toxic environmental pollutant that can disrupt the immune system of the human body. Benzene exposure has been reported to reduce immune cells in multiple immune organs. This study used quantitative proteomics to depict benzene-induced spleen injury.

2023-02-08 | PXD039948 |

Polysome propensity and tunable thresholds in coding sequence length enable differential mRNA stability

Project description:The half-life of mRNAs, as well as their translation, increases proportionally to the optimal codons, indicating a tight coupling of codon-dependent differential translation and degradation. Little is known about the regulation of this coupling. We found that the coupling in yeast displays a dichotomous behavior regarding the mRNA coding sequence length. Below a critical length, codon optimality fails to affect the stability of mRNAs even though they can be efficiently translated into short peptides and proteins. Above this threshold length, codon optimality-dependent differential mRNA stability emerges in a switch-like fashion, which coincides with a similar increase in the polysome propensity of the mRNAs. This threshold length can be tuned by the untranslated regions (UTR). Some of these UTRs can destabilize mRNAs without reducing translation, which plays a role in controlling the amplitude of the oscillatory expression of cell-cycle genes. Our findings help understand the translation of short peptides from noncoding RNAs and the translation by localized monosomes in neurons.

2023-09-28 | GSE235627 | GEO

Effect of deletion of carnitine palmitoyltransferase2 on interscapular BAT gene expression upon adrenergic stimulation in thermoneutral acclimatized mice

Project description:Ambient temperature affects energy intake and expenditure to maintain homeostasis in a continuously fluctuating environment. Here, mice with an adipose-specific defect in fatty acid oxidation (Cpt2A-/-) were subjected to varying temperature to determine the role of adipose bioenergetics to environmental adaptation. Cpt2A-/- brown adipose tissue (BAT) failed to induce thermogenic genes such as Ucp1 and Pgc1α in response to adrenergic stimulation, which is exacerbated by increasing temperature. Thermoneutrality induced a mitochondrial DNA stress in Cpt2A-/- BAT that resulted in a loss of classical interscapular BAT, but did not affect body weight gain or glucose tolerance in response to a high-fat diet. In this dataset, we include the expression data obtained from dissected mouse interscapular brown adipose tissue from mice acclimatized to thermoneutrality (30C) with and without beta3adrenergic stimulation with and without the deletion of carnitine palmitoyltransferase 2 (i.e., adipose unable to beta-oxidize long chain fatty acids in mitochondria).

2016-02-04 | GSE72210 | GEO

Effect of deletion of carnitine palmitoyltransferase2 on interscapular BAT gene expression upon adrenergic stimulation in thermoneutral acclimatized mice

Project description:Ambient temperature affects energy intake and expenditure to maintain homeostasis in a continuously fluctuating environment. Here, mice with an adipose-specific defect in fatty acid oxidation (Cpt2A-/-) were subjected to varying temperature to determine the role of adipose bioenergetics to environmental adaptation. Cpt2A-/- brown adipose tissue (BAT) failed to induce thermogenic genes such as Ucp1 and Pgc1Î± in response to adrenergic stimulation, which is exacerbated by increasing temperature. Thermoneutrality induced a mitochondrial DNA stress in Cpt2A-/- BAT that resulted in a loss of classical interscapular BAT, but did not affect body weight gain or glucose tolerance in response to a high-fat diet. In this dataset, we include the expression data obtained from dissected mouse interscapular brown adipose tissue from mice acclimatized to thermoneutrality (30C) with and without beta3adrenergic stimulation with and without the deletion of carnitine palmitoyltransferase 2 (i.e., adipose unable to beta-oxidize long chain fatty acids in mitochondria). WildType and Cpt2A KnockOut mice were treated either with or without beta3adrenergic stimulation, thus four classes. Three biologic replicates were compared per class, thus twelve mice.

2016-02-04 | E-GEOD-72210 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data