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Jarrett2015 - Modelling the interaction between immune response, bacterial dynamics and inflammatory damage


ABSTRACT: Mathematical model of pro- and anti-inflammatory response, inflammation/damage and infection dynamics in BALB/c mouse with Staphylococcal aureus infection.

SUBMITTER: Matthew Roberts  

PROVIDER: BIOMD0000000920 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Modelling the interaction between the host immune response, bacterial dynamics and inflammatory damage in comparison with immunomodulation and vaccination experiments.

Jarrett Angela M AM   Cogan N G NG   Shirtliff M E ME  

Mathematical medicine and biology : a journal of the IMA 20140508 3


The immune system is a complex system of chemical and cellular interactions that responds quickly to queues that signal infection and then reverts to a basal level once the challenge is eliminated. Here, we present a general, four-component model of the immune system's response to a Staphylococcal aureus (S. aureus) infection, using ordinary differential equations. To incorporate both the infection and the immune system, we adopt the style of compartmenting the system to include bacterial dynami  ...[more]

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