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Rhodes2019 - Immune-Mediated theory of Metastasis

ABSTRACT: Abstract: Accumulating experimental and clinical evidence suggest that the immune response to cancer is not exclusively anti-tumor. Indeed, the pro-tumor roles of the immune system - as suppliers of growth and pro-angiogenic factors or defenses against cytotoxic immune attacks, for example - have been long appreciated, but relatively few theoretical works have considered their effects. Inspired by the recently proposed "immune-mediated" theory of metastasis, we develop a mathematical model for tumor-immune interactions at two anatomically distant sites, which includes both anti- and pro-tumor immune effects, and the experimentally observed tumor-induced phenotypic plasticity of immune cells (tumor "education" of the immune cells). Upon confrontation of our model to experimental data, we use it to evaluate the implications of the immune-mediated theory of metastasis. We find that tumor education of immune cells may explain the relatively poor performance of immunotherapies, and that many metastatic phenomena, including metastatic blow-up, dormancy, and metastasis to sites of injury, can be explained by the immune-mediated theory of metastasis. Our results suggest that further work is warranted to fully elucidate the pro-tumor effects of the immune system in metastatic cancer.

SUBMITTER: Szeyi Ng

PROVIDER: BIOMD0000000926 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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	BIOMD0000000926?filename=Rhodes2019-Immune-Mediated%20theory%20of%20Metastasis-biopax2.owl	Owl
	BIOMD0000000926?filename=Rhodes2019-Immune-Mediated%20theory%20of%20Metastasis-biopax3.owl	Owl
	BIOMD0000000926?filename=Rhodes2019-Immune-Mediated%20theory%20of%20Metastasis-matlab.m	Other
	BIOMD0000000926?filename=Rhodes2019-Immune-Mediated%20theory%20of%20Metastasis-octave.m	Other
	BIOMD0000000926?filename=Rhodes2019-Immune-Mediated%20theory%20of%20Metastasis.cps	Other

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Rhodes2019 - Immune-Mediated theory of Metastasis

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