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Kosiuk2015-Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle

ABSTRACT: A minimal model describing the embryonic cell division cycle at the molecular level in eukaryotes is analyzed mathematically. It is known from numerical simulations that the corresponding three-dimensional system of ODEs has periodic solutions in certain parameter regimes. We prove the existence of a stable limit cycle and provide a detailed description on how the limit cycle is generated. The limit cycle corresponds to a relaxation oscillation of an auxiliary system, which is singularly perturbed and has the same orbits as the original model. The singular perturbation character of the auxiliary problem is caused by the occurrence of small Michaelis constants in the model. Essential pieces of the limit cycle of the auxiliary problem consist of segments of slow motion close to several branches of a two dimensional critical manifold which are connected by fast jumps. In addition, a new phenomenon of exchange of stability occurs at lines, where the branches of the two-dimensional critical manifold intersect. This novel type of relaxation oscillations is studied by combining standard results from geometric singular perturbation with several suitable blow-up transformations.

SUBMITTER: Ahmad Zyoud

PROVIDER: BIOMD0000000933 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000933?filename=Kosiuk2015-biopax2.owl	Owl
	BIOMD0000000933?filename=Kosiuk2015-biopax3.owl	Owl
	BIOMD0000000933?filename=Kosiuk2015-matlab.m	Other
	BIOMD0000000933?filename=Kosiuk2015-octave.m	Other
	BIOMD0000000933?filename=Kosiuk2015.cps	Other

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Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle.

Kosiuk Ilona I Szmolyan Peter P

Journal of mathematical biology 20150623 5

A minimal model describing the embryonic cell division cycle at the molecular level in eukaryotes is analyzed mathematically. It is known from numerical simulations that the corresponding three-dimensional system of ODEs has periodic solutions in certain parameter regimes. We prove the existence of a stable limit cycle and provide a detailed description on how the limit cycle is generated. The limit cycle corresponds to a relaxation oscillation of an auxiliary system, which is singularly perturb ...[more]

PMID: 26100376

Publication: 1/2

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