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Goldbeter2013-Oscillatory activity of cyclin-dependent kinases in the cell cycle


ABSTRACT: A model for oscillations of Cdc2 kinase in embryonic cell cycles based on Michaelis–Menten phosphorylation–dephosphorylation kinetics shows that the occurrence and amplitude of the oscillations strongly depend on the ultrasensitivity of the enzymatic cascade that controls the activity of the cyclin-dependent kinase.

SUBMITTER: Ahmad Zyoud  

PROVIDER: BIOMD0000000944 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Oscillatory enzyme reactions and Michaelis-Menten kinetics.

Goldbeter Albert A  

FEBS letters 20130723 17


Oscillations occur in a number of enzymatic systems as a result of feedback regulation. How Michaelis-Menten kinetics influences oscillatory behavior in enzyme systems is investigated in models for oscillations in the activity of phosphofructokinase (PFK) in glycolysis and of cyclin-dependent kinases in the cell cycle. The model for the PFK reaction is based on a product-activated allosteric enzyme reaction coupled to enzymatic degradation of the reaction product. The Michaelian nature of the pr  ...[more]

Publication: 1/2

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