Dataset Information

Lee2017 - Paracetamol first-pass metabolism PK model

ABSTRACT: Authors developed a microfluidic gut-liver co-culture chip that aims to reproduce the first-pass metabolism of oral drugs. The study suggests the possibility of reproducing the human PK profile on a chip, contributing to accurate prediction of pharmacological effect of drugs.

SUBMITTER: Matthew Roberts

PROVIDER: BIOMD0000000947 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000947?filename=Evans2005.sedml	Other
	BIOMD0000000947?filename=Lee2017_Paracetamol_Metabolism.cps	Other
	BIOMD0000000947?filename=Lee2017_Paracetamol_Metabolism.xml	Xml
	BIOMD0000000947?filename=figure.jpg	Other

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3D gut-liver chip with a PK model for prediction of first-pass metabolism.

Lee Dong Wook DW Ha Sang Keun SK Choi Inwook I Sung Jong Hwan JH

Biomedical microdevices 20171107 4

Accurate prediction of first-pass metabolism is essential for improving the time and cost efficiency of drug development process. Here, we have developed a microfluidic gut-liver co-culture chip that aims to reproduce the first-pass metabolism of oral drugs. This chip consists of two separate layers for gut (Caco-2) and liver (HepG2) cell lines, where cells can be co-cultured in both 2D and 3D forms. Both cell lines were maintained well in the chip, verified by confocal microscopy and measuremen ...[more]

PMID: 29116458

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