Models

Dataset Information

0

Palmer2008 - Negative Feedback in IL-7 mediated Jak-Stat signaling

ABSTRACT: Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstalk, shared interaction domains, feedback loops, integrated gene regulation, multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.

SUBMITTER: Gladys Langi  

PROVIDER: BIOMD0000000968 | BioModels | 2024-09-02

REPOSITORIES: BioModels

Json Xml

Dataset's files

Source:
Action DRS
BIOMD0000000968?filename=Palmer2008.cps Other
BIOMD0000000968?filename=Palmer2008.omex Other
BIOMD0000000968?filename=Palmer2008.sedml Other
BIOMD0000000968?filename=Palmer2008.xml Xml
Items per page:
1 - 4 of 4
altmetric image

Publications

Interleukin-7 receptor signaling network: an integrated systems perspective.

Palmer Megan J MJ   Mahajan Vinay S VS   Trajman Lily C LC   Irvine Darrell J DJ   Lauffenburger Douglas A DA   Chen Jianzhu J  

Cellular & molecular immunology 20080401 2

Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 r  ...[more]

Similar Datasets

Proteomics Characterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
2017-03-31 | MSV000080850 | MassIVE
Proteomics Characterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
2016-08-08 | PXD002386 | Pride
Genomics Regulating Interleukin-2 activity with engineered receptor signaling clamps
2015-06-16 | E-GEOD-64713 | biostudies-arrayexpress
Transcriptomics Regulating Interleukin-2 activity with engineered receptor signaling clamps
2015-06-16 | GSE64713 | GEO
Proteomics A comprehensive set of ER PDI family members supports the biogenesis of pro-inflammatory interleukin 12 family cytokines
2022-11-28 | PXD036463 | Pride
Transcriptomics Exon level expression profile of submandibular glands in female MyD88+/+ and MyD88−/− NOD mice.
2021-09-01 | GSE157669 | GEO
Transcriptomics Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15
2012-11-01 | E-GEOD-40350 | biostudies-arrayexpress
Transcriptomics Profiling of differentially expressed genes in sheep T lymphocytes response to Haemonchus contortus infection
2012-11-16 | E-GEOD-42302 | biostudies-arrayexpress
Transcriptomics Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma
2022-05-27 | GSE200040 | GEO
Proteomics Phosphoproteomic analyses of IL-2 signaling reveals integrated JAK-dependent and independent phosphorylation networks that drive cytotoxic T cell fate
2016-08-25 | PXD004645 | Pride