Dataset Information

Strasen2018 - TGFb SMAD Signalling Class 1

ABSTRACT: Model depicting response Class 1 defined by a minimal response to stimulation which is considered as non‐responders.

SUBMITTER: uddipan sarma

PROVIDER: BIOMD0000000998 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:

			Action	DRS
	BIOMD0000000998?filename=Figure_5A_class1-biopax2.owl	Owl
	BIOMD0000000998?filename=Figure_5A_class1-biopax3.owl	Owl
	BIOMD0000000998?filename=Figure_5A_class1-matlab.m	Other
	BIOMD0000000998?filename=Figure_5A_class1-octave.m	Other
	BIOMD0000000998?filename=Figure_5A_class1.ode	Other

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Publications

Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.

Strasen Jette J Sarma Uddipan U Jentsch Marcel M Bohn Stefan S Sheng Caibin C Horbelt Daniel D Knaus Petra P Legewie Stefan S Loewer Alexander A

Molecular systems biology 20180125 1

The cytokine TGFβ provides important information during embryonic development, adult tissue homeostasis, and regeneration. Alterations in the cellular response to TGFβ are involved in severe human diseases. To understand how cells encode the extracellular input and transmit its information to elicit appropriate responses, we acquired quantitative time-resolved measurements of pathway activation at the single-cell level. We established dynamic time warping to quantitatively compare signaling dyna ...[more]

PMID: 29371237

Dataset Information

Strasen2018 - TGFb SMAD Signalling Class 1

Dataset's files

Publications

Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.

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