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Ciliberto2005 - Steady states and oscillations in the p53/Mdm2 network


ABSTRACT: Its a mathematial model studying steady state and oscialltions in p53-MDM2 network triggered by IR induced DNA Damage.

SUBMITTER: Krishna Kumar Tiwari  

PROVIDER: BIOMD0000001006 | BioModels | 2024-09-02

REPOSITORIES: BioModels

Dataset's files

Source:
Action DRS
BIOMD0000001006?filename=Ciliberto2005.cps Other
BIOMD0000001006?filename=Ciliberto2005.sedml Other
BIOMD0000001006?filename=Ciliberto2005.xml Xml
BIOMD0000001006?filename=p53-Mdm2.ode Other
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Publications

Steady states and oscillations in the p53/Mdm2 network.

Ciliberto Andrea A   Novak Béla B   Tyson John J JJ  

Cell cycle (Georgetown, Tex.) 20050318 3


p53 is activated in response to events compromising the genetic integrity of a cell. Recent data show that p53 activity does not increase steadily with genetic damage but rather fluctuates in an oscillatory fashion. Theoretical studies suggest that oscillations can arise from a combination of positive and negative feedbacks or from a long negative feedback loop alone. Both negative and positive feedbacks are present in the p53/Mdm2 network, but it is not known what roles they play in the oscilla  ...[more]

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