Ontology highlight
ABSTRACT:
SUBMITTER: Emilia Chen
PROVIDER: BIOMD0000001025 | BioModels | 2024-09-02
REPOSITORIES: BioModels
Items per page: 1 - 5 of 12 |
Journal of clinical pharmacology 20201001
Chimeric antigen receptor T cell (CAR-T cell) therapies have shown significant efficacy in CD19+ leukemias and lymphomas. There remain many challenges and questions for improving next-generation CAR-T cell therapies, and mathematical modeling of CAR-T cells may play a role in supporting further development. In this review, we introduce a mathematical modeling taxonomy for a set of relatively simple cellular kinetic-pharmacodynamic models that describe the in vivo dynamics of CAR-T cell and their ...[more]