Dataset Information

Csikasz-Nagy2006 - Mammalian Cell Cycle model

ABSTRACT: This model originates from the Cell Cycle Database . It is described in: Analysis of a generic model of eukaryotic cell-cycle regulation. Csikász-Nagy A , Battogtokh D , Chen KC , Novák B , Tyson JJ Biophys. J. [2006 Jun],90(12 ):4361-79 PMID: 16581849 Abstract: We propose a protein interaction network for the regulation of DNA synthesis and mitosis that emphasizes the universality of the regulatory system among eukaryotic cells. The idiosyncrasies of cell cycle regulation in particular organisms can be attributed, we claim, to specific settings of rate constants in the dynamic network of chemical reactions. The values of these rate constants are determined ultimately by the genetic makeup of an organism. To support these claims, we convert the reaction mechanism into a set of governing kinetic equations and provide parameter values (specific to budding yeast, fission yeast, frog eggs, and mammalian cells) that account for many curious features of cell cycle regulation in these organisms. Using one-parameter bifurcation diagrams, we show how overall cell growth drives progression through the cell cycle, how cell-size homeostasis can be achieved by two different strategies, and how mutations remodel bifurcation diagrams and create unusual cell-division phenotypes. The relation between gene dosage and phenotype can be summarized compactly in two-parameter bifurcation diagrams. Our approach provides a theoretical framework in which to understand both the universality and particularity of cell cycle regulation, and to construct, in modular fashion, increasingly complex models of the networks controlling cell growth and division. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Nicolas Le Novère

PROVIDER: BIOMD0000001044 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000001044?filename=Csikasz-Nagy2006.cps	Other
	BIOMD0000001044?filename=Csikasz-Nagy2006.sedml	Other
	BIOMD0000001044?filename=Csikasz-Nagy2006.xml	Xml
	BIOMD0000001044?filename=MODEL3897771820-biopax2.owl	Owl
	BIOMD0000001044?filename=MODEL3897771820-biopax3.owl	Owl

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Publications

Analysis of a generic model of eukaryotic cell-cycle regulation.

Csikász-Nagy Attila A Battogtokh Dorjsuren D Chen Katherine C KC Novák Béla B Tyson John J JJ

Biophysical journal 20060331 12

We propose a protein interaction network for the regulation of DNA synthesis and mitosis that emphasizes the universality of the regulatory system among eukaryotic cells. The idiosyncrasies of cell cycle regulation in particular organisms can be attributed, we claim, to specific settings of rate constants in the dynamic network of chemical reactions. The values of these rate constants are determined ultimately by the genetic makeup of an organism. To support these claims, we convert the reaction ...[more]

PMID: 16581849

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