ABSTRACT:
This a model from the article:
Cardiac sodium channel Markov model with temperature dependence and recovery
from inactivation.
Irvine LA, Jafri MS, Winslow RL. Biophys J
1999 Apr;76(4):1868-85 10096885
,
Abstract:
A Markov model of the cardiac sodium channel is presented. The model is similar
to the CA1 hippocampal neuron sodium channel model developed by Kuo and Bean
(1994. Neuron. 12:819-829) with the following modifications: 1) an additional
open state is added; 2) open-inactivated transitions are made voltage-dependent;
and 3) channel rate constants are exponential functions of enthalpy, entropy,
and voltage and have explicit temperature dependence. Model parameters are
determined using a simulated annealing algorithm to minimize the error between
model responses and various experimental data sets. The model reproduces a wide
range of experimental data including ionic currents, gating currents, tail
currents, steady-state inactivation, recovery from inactivation, and open time
distributions over a temperature range of 10 degrees C to 25 degrees C. The
model also predicts measures of single channel activity such as first latency,
probability of a null sweep, and probability of reopening.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Irvine LA, Jafri MS, Winslow RL. (1999) - version02
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute
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Vijayalakshmi Chelliah 