ABSTRACT:
This a model from the article:
A simplified local control model of calcium-induced calcium release in cardiac
ventricular myocytes.
Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. Biophys J
2004 Dec;87(6):3723-36 15465866
,
Abstract:
Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high
gain and is graded. These properties result from local control of Ca2+ release.
Existing local control models of Ca2+ release in which interactions between
L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs)
are simulated stochastically are able to reconstruct these properties, but only
at high computational cost. Here we present a general analytical approach for
deriving simplified models of local control of CICR, consisting of
low-dimensional systems of coupled ordinary differential equations, from these
more complex local control models in which LCC-RyR interactions are simulated
stochastically. The resulting model, referred to as the coupled LCC-RyR gating
model, successfully reproduces a range of experimental data, including L-Type
Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current
with and without Ca2+ release from the sarcoplasmic reticulum,
voltage-dependence of excitation-contraction coupling gain, graded release, and
the force-frequency relationship. The model does so with low computational cost.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. (2004) - version02
The original CellML model was created by:
Terkildsen, Jonna,
j.terkildsen@auckland.ac.nz
University of Auckland
Auckland Bioengineering Institute
This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication
for more information.
In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.