ABSTRACT:
This a model from the article:
Constancy and variability of contractile efficiency as a function of calcium and
cross-bridge kinetics: simulation.
Yamaguchi H, Takaki M, Matsubara H, Yasuhara S, Suga H. Am J Physiol
1996 Apr;270(4 Pt 2):H1501-8 8967394
,
Abstract:
We simulated myocardial Ca2+ (Ca) and cross-bridge (CB) kinetics to get insight
into the experimentally observed constancy and variability of cardiac
contractile efficiency in generating total mechanical energy under various
inotropic and pathological conditions. The simulation consisted of a Ca
transient, Ca association and dissociation rate constants of troponin C, and CB
on and off rate constants. We evaluated sarcomere isometric twitch contractions
at a constant muscle length. We assumed that each CB cycle hydrolyzes one ATP
and that the force-length area (FLA) quantifies the total mechanical energy
generated by CB cycles in a twitch contraction. FLA is a linear version of
pressure-volume area, which quantifies the total mechanical energy of cardiac
twitch contraction and correlates linearly with cardiac oxygen consumption (H.
Suga, Physiol. Rev. 70: 247-277, 1990). The simulation shows that the
contractile efficiency varies with changes in the Ca transient and Ca and CB
kinetics except when they simultaneously speed up or slow down proportionally.
These results point to possible mechanisms underlying the constancy and
variability of cardiac contractile efficiency.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Yamaguchi H, Takaki M, Matsubara H, Yasuhara S, Suga H. (1996) - version=1.0
The original CellML model was created by:
Geoffrey Nunns
gnunns1@jhu.edu
The University of Auckland
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
Camille Laibe 
