Mazemondet2012 - beta-catenin dynamics in human neural progenitor cells
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ABSTRACT:
SUBMITTER: 
Orianne Mazemondet
PROVIDER: MODEL1303140000 | BioModels | 2005-01-01
REPOSITORIES: BioModels
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Publications
Elucidating the sources of β-catenin dynamics in human neural progenitor cells.
Mazemondet Orianne O John Mathias M Leye Stefan S Rolfs Arndt A Uhrmacher Adelinde M AM
PloS one 20120820 8
Human neural progenitor cells (hNPCs) form a new prospect for replacement therapies in the context of neurodegenerative diseases. The Wnt/β-catenin signaling pathway is known to be involved in the differentiation process of hNPCs. RVM cells form a common cell model of hNPCs for in vitro investigation. Previous observations in RVM cells raise the question of whether observed kinetics of the Wnt/β-catenin pathway in later differentiation phases are subject to self-induced signaling. However, a con ...[more]
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