Dataset Information

VanEunen2012 - Yeast Glycolysis (glucose upshift)

ABSTRACT: This is corresponding to the model of yeast glycolysis "glucose upshift" condition described in the paper "Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics" by van Eunen et al published in Plos Comput Biol, 2012.

SUBMITTER: Shodhan Rao

PROVIDER: MODEL1403250001 | BioModels | 2014-09-15

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1403250001?filename=MODEL1403250001-biopax2.owl	Owl
	MODEL1403250001?filename=MODEL1403250001-biopax3.owl	Owl
	MODEL1403250001?filename=MODEL1403250001.m	Other
	MODEL1403250001?filename=MODEL1403250001.pdf	Pdf
	MODEL1403250001?filename=MODEL1403250001.png	Other

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Publications

Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics.

van Eunen Karen K Kiewiet José A L JA Westerhoff Hans V HV Bakker Barbara M BM

PLoS computational biology 20120426 4

A decade ago, a team of biochemists including two of us, modeled yeast glycolysis and showed that one of the most studied biochemical pathways could not be quite understood in terms of the kinetic properties of the constituent enzymes as measured in cell extract. Moreover, when the same model was later applied to different experimental steady-state conditions, it often exhibited unrestrained metabolite accumulation.Here we resolve this issue by showing that the results of such ab initio modeling ...[more]

PMID: 22570597

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