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Miao2014 - Dynamics and migratory pathways of virus-specific antibody-secreting cell populations

ABSTRACT: This model is from the paper available at http://www.ncbi.nlm.nih.gov/pubmed/25171166. The original model contains time-varying parameters which are described by a smoothing spline. In this model parameters S1 and S2 are placeholders for these time-varying parameters. The model can be explored and executed through DEDiscover, with session file available at http://tinyurl.com/mc9cl77.

SUBMITTER: Alain Leblanc

PROVIDER: MODEL1411130000 | BioModels | 2015-04-15

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1411130000?filename=MODEL1411130000-biopax2.owl	Owl
	MODEL1411130000?filename=MODEL1411130000-biopax3.owl	Owl
	MODEL1411130000?filename=MODEL1411130000.m	Other
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	MODEL1411130000?filename=MODEL1411130000.png	Other

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Publications

Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection.

Miao Hongyu H Sangster Mark Y MY Livingstone Alexandra M AM Hilchey Shannon P SP Zhang Le L Topham David J DJ Mosmann Tim R TR Holden-Wiltse Jeanne J Perelson Alan S AS Wu Hulin H Zand Martin S MS

PloS one 20140829 8

The B cell response to influenza infection of the respiratory tract contributes to viral clearance and establishes profound resistance to reinfection by related viruses. Numerous studies have measured virus-specific antibody-secreting cell (ASC) frequencies in different anatomical compartments after influenza infection and provided a general picture of the kinetics of ASC formation and dispersion. However, the dynamics of ASC populations are difficult to determine experimentally and have receive ...[more]

PMID: 25171166

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