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Millard2016 - E. coli central carbon and energy metabolism

ABSTRACT: Millard2016 - E. coli central carbon and energy metabolism This model is described in the article: Metabolic regulation is sufficient for global and robust coordination of glucose uptake, catabolism, energy production and growth in Escherichia coli Pierre Millard , Kieran Smallbone, Pedro Mendes PLoS ONE Abstract: The metabolism of microorganisms is regulated through two main mechanisms: changes of enzyme capacities as a consequence of gene expression modulation (“hierarchical control”) and changes of enzyme activities through metabolite-enzyme interactions. An increasing body of evidence indicates that hierarchical control is insufficient to explain metabolic behaviors, but the system-wide impact of metabolic regulation remains largely uncharacterized. To clarify its role, we developed and validated a detailed kinetic model of Escherichia coli central metabolism that links growth to environment. Metabolic control analyses confirm that the control is widely distributed across the network and highlight strong interconnections between all the pathways. Exploration of the model solution space reveals that several robust properties emerge from metabolic regulation, from the molecular level (e.g. homeostasis of total metabolite pool) to the overall cellular physiology (e.g. coordination of carbon uptake, catabolism, energy and redox production, and growth), while allowing a large degree of flexibility at most individual metabolic steps. These properties have important physiological implications for E. coli and significantly expand the self-regulating capacities of its metabolism. This model is hosted on BioModels Database and identified by: MODEL1505110000. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Pierre Millard

PROVIDER: MODEL1505110000 | BioModels | 2017-02-21

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1505110000?filename=MODEL1505110000.cellml	Other
	MODEL1505110000?filename=MODEL1505110000.m	Other
	MODEL1505110000?filename=MODEL1505110000.png	Other
	MODEL1505110000?filename=MODEL1505110000.sci	Other
	MODEL1505110000?filename=MODEL1505110000.svg	Svg

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Millard2016 - E. coli central carbon and energy metabolism

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