Dataset Information

AbuOun2009 - Genome-scale metabolic network of Salmonella typhimurium (iMA945)

ABSTRACT: AbuOun2009 - Genome-scale metabolic network of Salmonella typhimurium (iMA945) This model is described in the article: Genome scale reconstruction of a Salmonella metabolic model: comparison of similarity and differences with a commensal Escherichia coli strain. AbuOun M, Suthers PF, Jones GI, Carter BR, Saunders MP, Maranas CD, Woodward MJ, Anjum MF. J. Biol. Chem. 2009 Oct; 284(43): 29480-29488 Abstract: Salmonella are closely related to commensal Escherichia coli but have gained virulence factors enabling them to behave as enteric pathogens. Less well studied are the similarities and differences that exist between the metabolic properties of these organisms that may contribute toward niche adaptation of Salmonella pathogens. To address this, we have constructed a genome scale Salmonella metabolic model (iMA945). The model comprises 945 open reading frames or genes, 1964 reactions, and 1036 metabolites. There was significant overlap with genes present in E. coli MG1655 model iAF1260. In silico growth predictions were simulated using the model on different carbon, nitrogen, phosphorous, and sulfur sources. These were compared with substrate utilization data gathered from high throughput phenotyping microarrays revealing good agreement. Of the compounds tested, the majority were utilizable by both Salmonella and E. coli. Nevertheless a number of differences were identified both between Salmonella and E. coli and also within the Salmonella strains included. These differences provide valuable insight into differences between a commensal and a closely related pathogen and within different pathogenic strains opening new avenues for future explorations. This model is hosted on BioModels Database and identified by: MODEL1507180009. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Nicolas Le Novère

PROVIDER: MODEL1507180009 | BioModels | 2015-07-30

REPOSITORIES: BioModels

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	MODEL1507180009?filename=MODEL1507180009-biopax3.owl	Owl
	MODEL1507180009?filename=MODEL1507180009.m	Other
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Publications

Genome scale reconstruction of a Salmonella metabolic model: comparison of similarity and differences with a commensal Escherichia coli strain.

AbuOun Manal M Suthers Patrick F PF Jones Gareth I GI Carter Ben R BR Saunders Mark P MP Maranas Costas D CD Woodward Martin J MJ Anjum Muna F MF

The Journal of biological chemistry 20090818 43

Salmonella are closely related to commensal Escherichia coli but have gained virulence factors enabling them to behave as enteric pathogens. Less well studied are the similarities and differences that exist between the metabolic properties of these organisms that may contribute toward niche adaptation of Salmonella pathogens. To address this, we have constructed a genome scale Salmonella metabolic model (iMA945). The model comprises 945 open reading frames or genes, 1964 reactions, and 1036 meta ...[more]

PMID: 19690172

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