Emiola2016 - Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biosynthesis,
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ABSTRACT:
SUBMITTER: 
Akintunde Emiola
PROVIDER: MODEL1601080000 | BioModels | 2016-03-01
REPOSITORIES: BioModels
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Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli.
Emiola Akintunde A Andrews Steven S SS Heller Carolin C George John J
Proceedings of the National Academy of Sciences of the United States of America 20160229 11
The outer membrane of gram-negative bacteria is composed of phospholipids in the inner leaflet and lipopolysaccharides (LPS) in the outer leaflet. LPS is an endotoxin that elicits a strong immune response from humans, and its biosynthesis is in part regulated via degradation of LpxC (EC 3.5.1.108) and WaaA (EC 2.4.99.12/13) enzymes by the protease FtsH (EC 3.4.24.-). Because the synthetic pathways for both molecules are complex, in addition to being produced in strict ratios, we developed a comp ...[more]
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