Dataset Information

Saa2016 - Mammalian methionine cycle - approximate bayesian computation

ABSTRACT: Construction of feasible and accurate kinetic models of metabolism: A Bayesian approach Pedro A. Saa, Lars K. Nielsen* Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia *Corresponding author Email: lars.nielsen@uq.edu.au Reference methionine cycle model (i.e., true model) used for parameter estimation. This model is almost entirely based on the kinetic reconstruction of Korendyaseva et al. (2008). Korendyaseva TK, Kuvatov DN, Volkov Va, Martinov MV, Vitvitsky VM, Banerjee R, Ataullakhanov FI (2008) An allosteric mechanism for switching between parallel tracks in mammalian sulfur metabolism. Plos Comput Biol 4: e1000076

SUBMITTER: Pedro Saa

PROVIDER: MODEL1603150000 | BioModels | 2016-07-17

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1603150000?filename=MODEL1603150000-biopax2.owl	Owl
	MODEL1603150000?filename=MODEL1603150000-biopax3.owl	Owl
	MODEL1603150000?filename=MODEL1603150000.m	Other
	MODEL1603150000?filename=MODEL1603150000.png	Other
	MODEL1603150000?filename=MODEL1603150000.sci	Other

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Publications

Construction of feasible and accurate kinetic models of metabolism: A Bayesian approach.

Saa Pedro A PA Nielsen Lars K LK

Scientific reports 20160715

Kinetic models are essential to quantitatively understand and predict the behaviour of metabolic networks. Detailed and thermodynamically feasible kinetic models of metabolism are inherently difficult to formulate and fit. They have a large number of heterogeneous parameters, are non-linear and have complex interactions. Many powerful fitting strategies are ruled out by the intractability of the likelihood function. Here, we have developed a computational framework capable of fitting feasible an ...[more]

PMID: 27417285

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