Dataset Information

Sier2017_E2_combined

ABSTRACT: Using scaling from PhysB model Blood flow in L/hr Compartments in Kg Baseline as ~0.003nM Free E2 in Blood_venous E2 biosynthesis rate constant = 2 E2 biosynthesis species = 1nM CLeh = 5 CLint = metabolic model T:P = 0.286

SUBMITTER: Nick Plant

PROVIDER: MODEL1711210002 | BioModels | 2018-02-02

REPOSITORIES: BioModels

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Dataset's files

Source:

			Action	DRS
	MODEL1711210002?filename=E2_PBPK_LiverODE_v7.3.xml	Xml

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Publications

Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology.

Sier Joanna H JH Thumser Alfred E AE Plant Nick J NJ

BMC systems biology 20171215 1

<h4>Background</h4>Estrogen is a vital hormone that regulates many biological functions within the body. These include roles in the development of the secondary sexual organs in both sexes, plus uterine angiogenesis and proliferation during the menstrual cycle and pregnancy in women. The varied biological roles of estrogens in human health also make them a therapeutic target for contraception, mitigation of the adverse effects of the menopause, and treatment of estrogen-responsive tumours. In ad ...[more]

PMID: 29246152

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