Dataset Information

Gnügge2016 - Synthetic switch Open loop circuit in yeast

ABSTRACT: This model was used to describe the behaviour of the synthetic open loop circuit in yeast, published in [1]. The accompanying script will simulate the model as used in main Figure 2c. Additional scaling and preprocessing was done to compare the model with data used in the experiment and can be obtained from the authors upon request. [1] Gnügge, Robert, et al. "An Orthogonal Permease–Inducer–Repressor Feedback Loop Shows Bistability." ACS synthetic biology 5.10 (2016): 1098-1107.

SUBMITTER: Lekshmi Dharmarajan

PROVIDER: MODEL1804240001 | BioModels | 2018-11-14

REPOSITORIES: BioModels

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Publications

An Orthogonal Permease-Inducer-Repressor Feedback Loop Shows Bistability.

Gnügge Robert R Dharmarajan Lekshmi L Lang Moritz M Stelling Jörg J

ACS synthetic biology 20160518 10

Feedback loops in biological networks, among others, enable differentiation and cell cycle progression, and increase robustness in signal transduction. In natural networks, feedback loops are often complex and intertwined, making it challenging to identify which loops are mainly responsible for an observed behavior. However, minimal synthetic replicas could allow for such identification. Here, we engineered a synthetic permease-inducer-repressor system in Saccharomyces cerevisiae to analyze if a ...[more]

PMID: 27148753

Dataset Information

Gnügge2016 - Synthetic switch Open loop circuit in yeast

Publications

An Orthogonal Permease-Inducer-Repressor Feedback Loop Shows Bistability.

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