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Luan2007 - Blood coagulation model combining previous models and platelet activation

ABSTRACT: Mathematical model combining previous models (Jones1994, Leipoldt1995, Kuhursky2001, Hockin2002) into one model with platelet activation.

SUBMITTER: Matthew Roberts

PROVIDER: MODEL1806050001 | BioModels | 2018-06-05

REPOSITORIES: BioModels

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Publications

Computationally derived points of fragility of a human cascade are consistent with current therapeutic strategies.

Luan Deyan D Zai Michael M Varner Jeffrey D JD

PLoS computational biology 20070701 7

The role that mechanistic mathematical modeling and systems biology will play in molecular medicine and clinical development remains uncertain. In this study, mathematical modeling and sensitivity analysis were used to explore the working hypothesis that mechanistic models of human cascades, despite model uncertainty, can be computationally screened for points of fragility, and that these sensitive mechanisms could serve as therapeutic targets. We tested our working hypothesis by screening a mod ...[more]

PMID: 17658944

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