Dataset Information

Mitrophanov2013 - Simulation of Hockin Blood Coagulation Model under reduced temperature

ABSTRACT: Blood coagulation model using an updated Hockin2002 model. New reactions for factor X and V activation by IXa and mIIa respectively (reactions R28 and R29, parameters k43 and k44). Changes to parameters k32 and k38 (appendix not found for cited reference [Danforth 2009] so parameters from Mitrophanov2011 were used). Model introduces formula for adjusting kinetic rates for reduced temperatures.

SUBMITTER: Matthew Roberts

PROVIDER: MODEL1806250002 | BioModels | 2018-06-25

REPOSITORIES: BioModels

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Publications

Computational analysis of the effects of reduced temperature on thrombin generation: the contributions of hypothermia to coagulopathy.

Mitrophanov Alexander Y AY Rosendaal Frits R FR Reifman Jaques J

Anesthesia and analgesia 20130718 3

<h4>Background</h4>Hypothermia, which can result from tissue hypoperfusion, body exposure, and transfusion of cold resuscitation fluids, is a major factor contributing to coagulopathy of trauma and surgery. Despite considerable efforts, the mechanisms of hypothermia-induced blood coagulation impairment have not been fully understood. We introduce a kinetic modeling approach to investigate the effects of hypothermia on thrombin generation.<h4>Methods</h4>We extended a validated computational mode ...[more]

PMID: 23868891

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