Model of budding yeast critical cell size dependence on growth rate with parameter set 3114
Ontology highlight
ABSTRACT:
SUBMITTER: 
Attila Csikász-Nagy
PROVIDER: MODEL1808310001 | BioModels | 2019-06-21
REPOSITORIES: BioModels
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| MODEL1808310001?filename=MolCompVol%20ps3114.cps | Other | |||
| MODEL1808310001?filename=MolCompVol%20ps3114.xml | Xml |
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Publications
Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress.
Moreno David F DF Parisi Eva E Yahya Galal G Vaggi Federico F Csikász-Nagy Attila A Aldea Martí M
Life science alliance 20190415 2
The precise coordination of growth and proliferation has a universal prevalence in cell homeostasis. As a prominent property, cell size is modulated by the coordination between these processes in bacterial, yeast, and mammalian cells, but the underlying molecular mechanisms are largely unknown. Here, we show that multifunctional chaperone systems play a concerted and limiting role in cell-cycle entry, specifically driving nuclear accumulation of the G1 Cdk-cyclin complex. Based on these findings ...[more]
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Project description:This model is described within the paper: A G1 arrest due to proteostasis decline delimits replicative lifespan in yeast
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To be implemented in Copasi.
Missing Event due to difficulties in SBML conversion to run model upon loading model in COPASI, create an event called Budding.
Set the trigger expression to: {Whi5.ParticleNumber} lt 250*({Whi5i.ParticleNumber}+{Whi5.ParticleNumber})/({Whi5.InitialParticleNumber}+{Whi5i.InitialParticleNumber}) AND {Values[Budding]} lt 1.
Uncheck boxes for fire at initial time if true and trigger must remain true.
Leave priority box blank.
Set delay to None.
There are 3 targets:
the value of budding which should be set to one;
the time at budding which should be set to the time;
and the unsynced generation which should be set to generation.
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