Ontology highlight
ABSTRACT:
SUBMITTER: Ashley Xavier
PROVIDER: MODEL1812210002 | BioModels | 2024-01-24
REPOSITORIES: BioModels
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MODEL1812210002?filename=Henze2017.xml | Xml |
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Henze Richard R Dittrich Peter P Ibrahim Bashar B
Scientific reports 20170620 1
The spindle assembly checkpoint (SAC) is an evolutionarily conserved mechanism, exclusively sensitive to the states of kinetochores attached to microtubules. During metaphase, the anaphase-promoting complex/cyclosome (APC/C) is inhibited by the SAC but it rapidly switches to its active form following proper attachment of the final spindle. It had been thought that APC/C activity is an all-or-nothing response, but recent findings have demonstrated that it switches steadily. In this study, we deve ...[more]