Dataset Information

Shaw2019 - Digital biosensor model from Yeast

ABSTRACT: SBML model exported from PottersWheel on 2018-06-29 21:50:11.

SUBMITTER: Graham Ladds

PROVIDER: MODEL1901300002 | BioModels | 2019-04-30

REPOSITORIES: BioModels

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Dataset's files

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			Action	DRS
	MODEL1901300002?filename=Yeast_Hillslope.xml	Xml

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Publications

Engineering a Model Cell for Rational Tuning of GPCR Signaling.

Shaw William M WM Yamauchi Hitoshi H Mead Jack J Gowers Glen-Oliver F GF Bell David J DJ Öling David D Larsson Niklas N Wigglesworth Mark M Ladds Graham G Ellis Tom T

Cell 20190404 3

G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to respond to specific cues in their environment. However, the relationship between stimulus and response for each GPCR is difficult to predict due to diversity in natural signal transduction architecture and expression. Using genome engineering in yeast, we constructed an insulated, modular GPCR signal transduction system to study how the response to stimuli can be predictably tuned using synthetic tools. We deline ...[more]

PMID: 30955892

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