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Ghaffari2019 - Thrombomodulin Gene Expression after Retinoic Acid Treatment for Cancer Patients with Coagulation Disorders

ABSTRACT: Publication includes a mathematical model for how retinoic acid affects thrombomodulin gene and mRNA expression as well as a two-compartment pharmacokinetic model for retinoic acid.

SUBMITTER: Matthew Roberts  

PROVIDER: MODEL1907140001 | BioModels | 2020-03-16

REPOSITORIES: BioModels

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MODEL1907140001?filename=Ghaffari2019.cps Other
MODEL1907140001?filename=Ghaffari2019_RA_PDPK.cps Other
MODEL1907140001?filename=Ghaffari2019_RA_PDPK.sedml Other
MODEL1907140001?filename=Ghaffari2019_RA_PDPK.xml Xml
MODEL1907140001?filename=Ghaffari2019_TM_exp.cps Other
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Publications

Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients.

Ghaffari Hamed H   Varner Jeffrey D JD   Petzold Linda R LR  

Theoretical biology & medical modelling 20190214 1

<h4>Background</h4>Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and bleeding complications such as disseminated intravascular coagulation (DIC). However, the mechanisms underlying this improvement have yet to be elucidated. In vitro studies have reported that RA upregulates thrombomodulin (TM) expression on the endothelial cell surface. The objective of this study was to investigate how and to w  ...[more]

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