Dataset Information

Lever2014 - Phenotypic models of T cell activation.

ABSTRACT: This is a phenotypic model of a kinetic proofreading mechanism used to describe dynamics governing interactions between T cell receptors and peptide-MHC complexes.

SUBMITTER: Johannes Meyer

PROVIDER: MODEL1907260003 | BioModels | 2019-11-13

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1907260003?filename=lever2014%20v5.0.cps	Other
	MODEL1907260003?filename=lever2014%20v5.0.xml	Xml

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Publications

Phenotypic models of T cell activation.

Lever Melissa M Maini Philip K PK van der Merwe P Anton PA Dushek Omer O

Nature reviews. Immunology 20140901 9

T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on the binding parameters that govern the interactions between T cell receptors (TCRs) and peptide-MHC complexes (pMHC complexes). Despite extensive experimental studies, the relationship between the TCR-pMHC binding parameters and T cell activation remains controversial. To make sense of conflicting experimental data, a variety of verbal and mathematical models have been proposed. However, it is currentl ...[more]

PMID: 25145757

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