DoldánMartelli2013 - A Mathematical Model for the Rational Design of Chimeric Ligands in Selective Drug Therapies
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ABSTRACT:
SUBMITTER: 
Johannes Meyer
PROVIDER: MODEL1907310001 | BioModels | 2019-07-31
REPOSITORIES: BioModels
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A mathematical model for the rational design of chimeric ligands in selective drug therapies.
Doldán-Martelli V V Guantes R R Míguez D G DG
CPT: pharmacometrics & systems pharmacology 20130213
Chimeric drugs with selective potential toward specific cell types constitute one of the most promising forefronts of modern Pharmacology. We present a mathematical model to test and optimize these synthetic constructs, as an alternative to conventional empirical design. We take as a case study a chimeric construct composed of epidermal growth factor (EGF) linked to different mutants of interferon (IFN). Our model quantitatively reproduces all the experimental results, illustrating how chimeras ...[more]
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