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Karlstaedt2019 - G6P accumulation via Phosphoglucose isomerase inhibition in heart muscles

ABSTRACT: This model is described in the article: Glucose 6-phosphate accumulates via phosphoglucose isomerase inhibition in heart muscle. Karlstaedt, A and Khanna, R and Thangam, M and Taegtmeyer, H Circulation Research (2019) The model describes glycolysis (including pyruvate oxidation and ATP turnover) in cardiomyocytes. An extension of the same model includes the pentose phosphate pathway.

SUBMITTER: Anja Karlstaedt

PROVIDER: MODEL1910170001 | BioModels | 2019-11-14

REPOSITORIES: BioModels

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Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle.

Karlstaedt Anja A Khanna Radhika R Thangam Manoj M Taegtmeyer Heinrich H

Circulation research 20191108 1

<h4>Rationale</h4>Metabolic and structural remodeling is a hallmark of heart failure. This remodeling involves activation of the mTOR (mammalian target of rapamycin) signaling pathway, but little is known on how intermediary metabolites are integrated as metabolic signals.<h4>Objective</h4>We investigated the metabolic control of cardiac glycolysis and explored the potential of glucose 6-phosphate (G6P) to regulate glycolytic flux and mTOR activation.<h4>Methods and results</h4>We developed a ki ...[more]

PMID: 31698999

Publication: 1/2

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