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Kawka2014 - Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model

ABSTRACT: This is a mathematical model of the Wnt signaling pathway in medulloblastoma comprised of two compartments. Composed of nine ordinary differential equations accounts for the formation and dissociation of complexes as well as the transcription, translation and transportation between the cytoplasm and the nucleus.

SUBMITTER: Johannes Meyer

PROVIDER: MODEL1912090002 | BioModels | 2019-12-09

REPOSITORIES: BioModels

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Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model.

Kawka Joanna J Sturm Dominik D Pleier Sabrina S Pfister Stefan S Marciniak-Czochra Anna A

Journal of theoretical biology 20140328

Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We f ...[more]

PMID: 24685888

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