Ontology highlight
ABSTRACT:
SUBMITTER: Mohammad Umer Sharif Shohan
PROVIDER: MODEL2001030002 | BioModels | 2024-09-26
REPOSITORIES: BioModels
Action | DRS | |||
---|---|---|---|---|
MODEL2001030002?filename=heberleRazquinNavas2019_model2.xml | Xml |
Items per page: 1 - 1 of 1 |
Life science alliance 20190328 2
All cells and organisms exhibit stress-coping mechanisms to ensure survival. Cytoplasmic protein-RNA assemblies termed stress granules are increasingly recognized to promote cellular survival under stress. Thus, they might represent tumor vulnerabilities that are currently poorly explored. The translation-inhibitory eIF2α kinases are established as main drivers of stress granule assembly. Using a systems approach, we identify the translation enhancers PI3K and MAPK/p38 as pro-stress-granule-kina ...[more]