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AhmedMobeen2021 - NF-kB Activation Model

ABSTRACT: NF-kappaB Activation Model includes the activation of both NFKB1:RELA and NFKB2:RELB for Canonical and Non-Canonical Pathway respectively. The model includes the pathway model integrated with post-translational modifications of NF-kB subunits that regulate the NFKB1:RELA and NFKB2:RELB activity. The processes that are regulated by NF-kB pathway can be monitored through following readouts NFKB1:RELA Activity, NFKB2:RELB Activity, Degraded RelA, Degraded RelB, Degraded IkB, Degraded NIK, Apoptosis, Tumour, Antiviral Activity, B Cell Growth and Cell Migration. However, last 5 processes above are also influenced by other pathways too, therefore while making predictions, caution has to be exercised.

SUBMITTER: Ahmed Mobeen  

PROVIDER: MODEL2001290001 | BioModels | 2022-05-27

REPOSITORIES: BioModels

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Publications

Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

McGillicuddy Fiona C FC   Chiquoine Elise H EH   Hinkle Christine C CC   Kim Roy J RJ   Shah Rachana R   Roche Helen M HM   Smyth Emer M EM   Reilly Muredach P MP  

The Journal of biological chemistry 20090923 46

Recent reports demonstrate T-cell infiltration of adipose tissue in early obesity. We hypothesized that interferon (IFN) gamma, a major T-cell inflammatory cytokine, would attenuate human adipocyte functions and sought to establish signaling mechanisms. Differentiated human adipocytes were treated with IFNgamma +/- pharmacological inhibitors prior to insulin stimulation. [(3)H]Glucose uptake and AKT phosphorylation were assessed as markers of insulin sensitivity. IFNgamma induced sustained loss  ...[more]

PMID: 19776010

Publication: 1/368

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