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Kolbe2019 - Spatio-temporal liver zonation

ABSTRACT: Metabolism of the adult liver in mice and human is spatially zonated with hepatocytes along the axis from each portal vein to the nearest central vein expressing enzymes in a zonated manner. Upstream of that functional zonation, interactions of Wnt and Hh signaling are orchestrating and self-organizing the spatial expression patterns. This spatio-temporal model is derived from experimental data and explores the interacting signaling pathways. To run this model, use the free, open-source software Morpheus (download for Windows, macOS, Linux from https://morpheus.gitlab.io).

SUBMITTER: Lutz Brusch

PROVIDER: MODEL2009110001 | BioModels | 2021-09-30

REPOSITORIES: BioModels

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Publications

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human.

Kolbe Erik E Aleithe Susanne S Rennert Christiane C Spormann Luise L Ott Fritzi F Meierhofer David D Gajowski Robert R Stöpel Claus C Hoehme Stefan S Kücken Michael M Brusch Lutz L Seifert Michael M von Schoenfels Witigo W Schafmayer Clemens C Brosch Mario M Hofmann Ute U Damm Georg G Seehofer Daniel D Hampe Jochen J Gebhardt Rolf R Matz-Soja Madlen M

Cell reports 20191201 13

The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years. How both pathways communicate and control liver metabolic functions are largely unknown. Detecting core components of Wnt and Hh signaling and mathematical modeling showed that both pathways in healthy liver act largely complementary to each other in the pericentral (Wnt) and the periportal zone (Hh) and communicate mainly by mutual r ...[more]

PMID: 31875560

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