Models

Dataset Information

0

Khandibharad2022 - IL-12 regulation by IL-10 in Leishmaniasis


ABSTRACT: In this model, TLR2-TLR6 mediates MyD88 pathway gets activated, which activates IL-12 production and induces iNOS expression when the Macrophage is infected with Leishmania parasite. The early induction of IL-10 takes place which leads to the induction of NFIL3, HDAC3, and SHP-1. They inhibit IL-12 production and thus hamper IL-12 induced IFN-gamma mediated; Nitric oxide production. A key transcription factor NFAT5 connects IL-12 and IL-10 pathways. It upregulates IL-12 and downregulates IL-10. In this model, NFAT5 is downregulated which is also inhibiting IL-12.

SUBMITTER: Shailza Singh  

PROVIDER: MODEL2012040002 | BioModels | 2022-01-24

REPOSITORIES: BioModels

Dataset's files

Source:
Action DRS
MODEL2012040002?filename=M2%20diseased%20model.xml Xml
Items per page:
1 - 1 of 1

Similar Datasets

2021-10-13 | GSE172060 | GEO
2021-10-13 | GSE147195 | GEO
2016-09-07 | GSE79809 | GEO
2009-10-08 | GSE18460 | GEO
2016-09-07 | E-GEOD-79809 | biostudies-arrayexpress
2009-10-20 | E-GEOD-18460 | biostudies-arrayexpress
2014-08-05 | GSE55834 | GEO
2009-03-03 | GSE15029 | GEO
2010-04-13 | E-GEOD-20087 | biostudies-arrayexpress
2009-03-03 | E-GEOD-15029 | biostudies-arrayexpress