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Hetmanski2021 rear retraction kinetic

ABSTRACT: Point models describing protein-protein signalling and membrane tension/contractility leading to rear retraction.

SUBMITTER: Joseph Hetmanski

PROVIDER: MODEL2103010001 | BioModels | 2021-10-18

REPOSITORIES: BioModels

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Publications

Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration.

Hetmanski Joseph H R JHR Jones Matthew C MC Chunara Fatima F Schwartz Jean-Marc JM Caswell Patrick T PT

PLoS computational biology 20210310 3

Cell migration in 3D microenvironments is a complex process which depends on the coordinated activity of leading edge protrusive force and rear retraction in a push-pull mechanism. While the potentiation of protrusions has been widely studied, the precise signalling and mechanical events that lead to retraction of the cell rear are much less well understood, particularly in physiological 3D extra-cellular matrix (ECM). We previously discovered that rear retraction in fast moving cells is a highl ...[more]

PMID: 33690598

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