Schölzel2021 - Modular model of the human cardiac conduction system based on Seidel-Herzel model (v1.1.1)
Ontology highlight
ABSTRACT:
SUBMITTER: 
Christopher Schölzel
PROVIDER: MODEL2103050002 | BioModels | 2021-03-08
REPOSITORIES: BioModels
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Project description:This a model from the article:
One-dimensional mathematical model of the atrioventricular node including
atrio-nodal, nodal, and nodal-his cells.
Inada S, Hancox JC, Zhang H, Boyett MR. Biophys J
2009 Oct 21;97(8):2117-27 19843444
,
Abstract:
Mathematical models are a repository of knowledge as well as research and
teaching tools. Although action potential models have been developed for most
regions of the heart, there is no model for the atrioventricular node (AVN). We
have developed action potential models for single atrio-nodal, nodal, and
nodal-His cells. The models have the same action potential shapes and
refractoriness as observed in experiments. Using these models, together with
models for the sinoatrial node (SAN) and atrial muscle, we have developed a
one-dimensional (1D) multicellular model including the SAN and AVN. The
multicellular model has slow and fast pathways into the AVN and using it we have
analyzed the rich behavior of the AVN. Under normal conditions, action
potentials were initiated in the SAN center and then propagated through the
atrium and AVN. The relationship between the AVN conduction time and the timing
of a premature stimulus (conduction curve) is consistent with experimental data.
After premature stimulation, atrioventricular nodal reentry could occur. After
slow pathway ablation or block of the L-type Ca(2+) current, atrioventricular
nodal reentry was abolished. During atrial fibrillation, the AVN limited the
number of action potentials transmitted to the ventricle. In the absence of SAN
pacemaking, the inferior nodal extension acted as the pacemaker. In conclusion,
we have developed what we believe is the first detailed mathematical model of
the AVN and it shows the typical physiological and pathophysiological
characteristics of the tissue. The model can be used as a tool to analyze the
complex structure and behavior of the AVN.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Inada S, Hancox JC, Zhang H, Boyett MR. (2009) - version=1.0
The original CellML model was created by:
Penny Noble
penny.noble@dpag.ox.ac.uk
The University of Oxford
This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
2005-01-01 | MODEL1006230008 | BioModels