Leander2021 - innate immune response to SARS-CoV-2 in the alveolar epithelium
Ontology highlight
ABSTRACT:
SUBMITTER: 
Krishna Kumar Tiwari
PROVIDER: MODEL2111170001 | BioModels | 2021-11-17
REPOSITORIES: BioModels
Dataset's files
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Publications
A model of the innate immune response to SARS-CoV-2 in the alveolar epithelium.
Leander R N RN Wu Y Y Ding W W Nelson D E DE Sinkala Z Z
Royal Society open science 20210811 8
We present a differential equation model of the innate immune response to SARS-CoV-2 within the alveolar epithelium. Critical determinants of the viral dynamics and host response, including type I and type II alveolar epithelial cells, interferons, chemokines, toxins and innate immune cells, are included. We estimate model parameters, compute the within-host basic reproductive number, and study the impacts of therapies, prophylactics, and host/pathogen variability on the course of the infection. ...[more]
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