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Immunological Healthy State Model of Sphingolipids with IL-6/IL-17/IL-23 immune axis in L.major infection

ABSTRACT: In Healthy State, we demonstrated the controlled expression of sphingolipids and the controlled IL-6,IL-17,IL-23 cytokines signalling via SOCS3 mediated regulation.

SUBMITTER: Shailza Singh

PROVIDER: MODEL2301110002 | BioModels | 2023-01-11

REPOSITORIES: BioModels

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Publications

Decoding systems immunological model of sphingolipids with IL-6/IL-17/IL-23 axes in L. major infection.

Jawale Diksha D Khandibharad Shweta S Singh Shailza S

Biochimica et biophysica acta. Molecular and cell biology of lipids 20221207 2

IL-6, IL-17, IL-23 and IL-1β are the crucial cytokines controlling inflammatory and immune response during L. major infection. During cutaneous leishmaniasis, an important T helper cell type CD4<sup>+</sup> Th17 subset plays a deterministic role in lesion formation through channelling infected macrophages and production of IL-1β, IL-6, IL-23 and IFN-γ. Ceramide derived sphingosine precursors may assist in pro-inflammatory cytokine response. However, the role of these metabolites in inflammation ...[more]

PMID: 36494028

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