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Mothes2020_NFkB_A20_signaling

ABSTRACT: The Mothes2020_NFkB_A20_signaling model is based on our previous model published in Murakawa et al., Nat Commun, 2015 (doi: 10.1038/ncomms8367). In the Mothes2020_NFkB_A20_signaling model, we removed the modulating impact of the component RC3H1 (RNA-binding protein ROQUIN) which can alter the degradation rates of A20_mRNA and IkBa_mRNA. The Mothes2020_NFkB_A20_signaling model therefore represents the wild type condition of the Murakawa model and shows identical dynamics of the included components A20, A20_mRNA, IkBa, IkBa_mRNA, NFkB, NFkB_IkBa and IKK_active.

SUBMITTER: Fabian Konrath  

PROVIDER: MODEL2307110001 | BioModels | 2023-07-11

REPOSITORIES: BioModels

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Publications

A Quantitative Modular Modeling Approach Reveals the Effects of Different A20 Feedback Implementations for the NF-kB Signaling Dynamics.

Mothes Janina J   Ipenberg Inbal I   Arslan Seda Çöl SÇ   Benary Uwe U   Scheidereit Claus C   Wolf Jana J  

Frontiers in physiology 20200728

Signaling pathways involve complex molecular interactions and are controled by non-linear regulatory mechanisms. If details of regulatory mechanisms are not fully elucidated, they can be implemented by different, equally reasonable mathematical representations in computational models. The study presented here focusses on NF-κB signaling, which is regulated by negative feedbacks via IκBα and A20. A20 inhibits NF-κB activation indirectly through interference with proteins that transduce the signal  ...[more]

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