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Green1985 - whole-body vitamin A metabolism in rats

ABSTRACT: The first known metabolic model of Vitamin A metabolism

SUBMITTER: Kieran Smallbone

PROVIDER: MODEL2311220001 | BioModels | 2024-03-08

REPOSITORIES: BioModels

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Publications

A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores.

Green M H MH Uhl L L Green J B JB

Journal of lipid research 19850701 7

A linear, first-order, constant-coefficient multicompartmental model is presented which describes the dynamics of [3H]retinol turnover in adult rats with normal plasma retinol concentrations but low liver stores (less than 100 micrograms of retinol equivalents). To fit plasma and tissue (liver, kidney, and rest of carcass) tracer and tracee data, eight physiological compartments were required in the model: two in plasma (proposed to correspond to the retinol transport complex, and retinyl esters ...[more]

PMID: 4040952

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