Ontology highlight
ABSTRACT:
SUBMITTER: Zainab Ashimiyu-Abdusalam
PROVIDER: MODEL2404220005 | BioModels | 2024-04-22
REPOSITORIES: BioModels
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Journal of cheminformatics 20200407 1
Over the last few decades, chemists have become skilled at designing compounds that avoid cytochrome P (CYP) 450 mediated metabolism. Typical screening assays are performed in liver microsomal fractions and it is possible to overlook the contribution of cytosolic enzymes until much later in the drug discovery process. Few data exist on cytosolic enzyme-mediated metabolism and no reliable tools are available to chemists to help design away from such liabilities. In this study, we screened 1450 co ...[more]