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Mechanotransduction & Inflammation

ABSTRACT: Deep review of our previous model MODEL2302150001 and publication Dent et al., 2015 (Mechanotransduction map: simulation model, molecular pathway, gene set) with more mechanical stimuli and specific attention to the impact on inflammation and on the AhR receptor.

SUBMITTER: Christine Nardini

PROVIDER: MODEL2406110001 | BioModels | 2024-06-17

REPOSITORIES: BioModels

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Publications

Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation.

Wei Linyu L Mousawi Fatema F Li Dongliang D Roger Sébastien S Li Jing J Yang Xuebin X Jiang Lin-Hua LH

Frontiers in pharmacology 20191106

Organs and tissues and their constituent cells are physiologically submitted to diverse types of mechanical forces or stress, one common sequence of which is release of intracellular ATP into extracellular space. Extracellular ATP is a well-established autocrine or paracrine signaling molecule that regulates multiple cell functions and mediates cell-to-cell communications <i>via</i> activating the purinergic P2 receptors, more specifically, ligand-gated ion channel P2X receptors and some of the ...[more]

PMID: 31780935

Publication: 1/33

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