Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Neisseria meningitidis wild type parent strain MC58 and NMB1966 knockout mutant which is impaired for invasion of respiratory epithelial cells, survival in human blood and for virulence in vivo


ABSTRACT: Data is also available from http://bugs.sgul.ac.uk/E-BUGS-67

ORGANISM(S): Neisseria meningitidis

SUBMITTER:  

PROVIDER: E-BUGS-67 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A Neisseria meningitidis NMB1966 mutant is impaired for invasion of respiratory epithelial cells, survival in human blood and for virulence in vivo.

Li Ming-Shi MS   Chow Noel Y S NY   Sinha Sunita S   Halliwell Denise D   Finney Michelle M   Gorringe Andrew R AR   Watson Mark W MW   Kroll J Simon JS   Langford Paul R PR   Webb Steven A R SA  

Medical microbiology and immunology 20081203 1


We sought to determine whether NMB1966, encoding a putative ABC transporter, has a role in pathogenesis. Compared to its isogenic wild-type parent strain Neisseria meningitidis MC58, the NMB1966 knockout mutant was less adhesive and invasive for human bronchial epithelial cells, had reduced survival in human blood and was attenuated in a systemic mouse model of infection. The transcriptome of the wild-type and the NMB1966 mutant was compared. The data are consistent with a previous functional as  ...[more]

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