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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human and mouse hematopoietic stem cells and other stages of the hematopoietic hierarchy, and to identify the shared expressed genes among the hematopoietic cells and neural and embryonic stem cells in mouse

ABSTRACT: Study to determine global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy, and to identify the shared expressed genes among the hematopoietic cells and neural and embryonic stem cells in mouse.

INSTRUMENT(S): Affymetrix Fluidics Station 400

ORGANISM(S): Mus musculus

SUBMITTER: Natalia Ivanova

PROVIDER: E-CBIL-33 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A stem cell molecular signature.

Ivanova Natalia B NB Dimos John T JT Schaniel Christoph C Hackney Jason A JA Moore Kateri A KA Lemischka Ihor R IR

Science (New York, N.Y.) 20020912 5593

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shar ...[more]

PMID: 12228721

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